Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extracellular matrix and neuronal movement.

P Liesi1

  • 1Institute of Biotechnology, University of Helsinki, Finland.

Experientia
|September 15, 1990
PubMed
Summary

Glial laminin guides developing neurons by providing attachment points and influencing pathways. This extracellular matrix protein is crucial for neuronal migration and axon guidance during brain development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biologically active sequence (KDI) mediates the neurite outgrowth function of the gamma-1 chain of laminin-1.

Journal of neuroscience research·2001
Same author

Involvement of non-NMDA receptors in the rescue of weaver cerebellar granule neurons and sensitivity to ethanol of cerebellar AMPA receptors in oocytes.

Brain research. Molecular brain research·2001
Same author

Neurons and glial cells of the embryonic human brain and spinal cord express multiple and distinct isoforms of laminin.

Journal of neuroscience research·2001
Same author

Involvement of GIRK2 in postnatal development of the weaver cerebellum.

Journal of neuroscience research·2000
Same author

Neurofilament proteins are constitutively expressed in F9 teratocarcinoma cells.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience·1999
Same author

Weaver cerebellar granule neurons show altered expression of NMDA receptor subunits both in vivo and in vitro.

Journal of neurobiology·1999

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Neuronal migration and axon guidance are critical processes during brain development.
  • Extracellular matrix (ECM) molecules play a significant role in regulating these cellular movements.
  • Glial laminin is an ECM protein that developing brain cells preferentially attach to.

Purpose of the Study:

  • To review the role of laminin in neuronal movement during brain development.
  • To discuss the interactions of ECM molecules, particularly laminin, in guiding developing neurons.
  • To highlight the significance of punctate laminin assemblies in neural pathway formation.

Main Methods:

  • Literature review focusing on extracellular matrix molecules and neuronal development.
  • Analysis of proposed interactions between laminin, glycosaminoglycans, and neuronal cells.
  • Synthesis of current concepts regarding the role of ECM in vivo.

Main Results:

  • Glial laminin serves as a key attachment substrate for migrating neuronal cell bodies and extending nerve fibers.
  • Extracellular glycosaminoglycans may act to restrict neuronal movement into specific brain regions.
  • Laminin deposition in punctate patterns along radial glial fibers and nerve pathways suggests a role in routing neurons.

Conclusions:

  • Laminin is a crucial ECM component influencing neuronal migration and axon guidance.
  • The spatial organization of laminin, particularly in punctate assemblies, is important for directing neuronal development.
  • Understanding laminin's interactions within the ECM provides insights into the mechanisms of neural circuit formation.

Related Experiment Videos