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Acute lymphoblastic leukemia in the elderly.

A Delannoy1, A Ferrant, A Bosly

  • 1Hôpital de Jolimont, La Louvière, Belgium.

European Journal of Haematology
|August 1, 1990
PubMed
Summary
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Elderly patients with acute lymphoblastic leukemia (ALL) face aggressive disease and poor tolerance to intensive therapy. Complete remission was short-lived, with a median survival of only 3 months in this study group.

Area of Science:

  • Hematology
  • Oncology
  • Geriatric Medicine

Background:

  • Acute lymphoblastic leukemia (ALL) is rare in individuals aged 60 years or older.
  • Treatment outcomes and prognostic factors in elderly ALL patients are not well-defined.

Purpose of the Study:

  • To describe the clinical characteristics, treatment outcomes, and prognostic factors of acute lymphoblastic leukemia (ALL) in patients aged 60 years or older.

Main Methods:

  • Retrospective analysis of 18 patients aged 60+ with ALL.
  • Review of clinical data, including morphology, immunophenotype, prognostic factors, and treatment regimens.
  • Evaluation of treatment response, remission duration, and survival.

Main Results:

  • A preleukemic syndrome was observed in 2 patients.

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  • L3 morphology was unexpectedly frequent (4/16), and T-ALL was not observed.
  • Prognostic factors such as high white blood cell count and CNS involvement were similar to younger adults.
  • Complete remission was achieved in 8 patients, but was short-lived.
  • Median survival for the entire group was 3 months.
  • 5 patients died in aplasia, and 5 failed to achieve remission.

    • Conclusions:

    • Acute lymphoblastic leukemia (ALL) in the elderly presents a therapeutic challenge due to aggressive disease and poor tolerance to intensive chemotherapy.
    • The findings highlight the need for tailored treatment strategies for elderly ALL patients.