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Nuclear factor-kappa B inhibitors; a patent review (2006-2010)
Jae-Hwan Kwak1, Jae-Kyung Jung, Heesoon Lee
1Chungbuk National University, College of Pharmacy, Cheongju 361-763, Republic of Korea.
Introduction:
Nuclear factor (NF)-κB, as transcription factor, is linked to the expression of various genes and plays an essential role in immune and inflammatory responses. Abnormal NF-κB signaling results in human diseases, such as immune disorders, inflammation and various cancers. Therefore, regulation of NF-κB may treat or improve the symptoms in human disorders.
Areas Covered:
This review provides information on recent NF-κB inhibitor-related patents from 2006 to 2010. The patents are explained and categorized by mechanism. The reader will gain an understanding of NF-κB function and the structure and biological activity of recently developed NF-κB inhibitors that may be new drug candidates.
Expert Opinion:
NF-κB plays an essential role in the human body and thus regulation of NF-κB is very important for the treatment of diseases. Furthermore, patented compounds and peptides are available as lead compounds in drug development studies.
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