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Updated: May 27, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
Published on: March 14, 2019
[Skull base osteomyelitis]
F Benoudiba1, F Toulgoat, J-L Sarrazin
1Service de neuroradiologie, CHU de Kremlin Bicêtre, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France. farida.benoudiba@bct.aphp.fr
Abstract:
Skull base osteomyelitis is a rare but serious infection. It typically afflicts immunosuppressed patients and should be suspected in patients with persistent otitis complicated by cranial nerve palsy (VII, IX and XII). The most frequent germ is pseudomonas aeruginosa. Contiguous spread of infection occurs along neurovascular structures and weaker regions of the skull base, then into the soft tissue compartments of the face and nasopharynx. Diagnosis and treatment should be made early for this disease with poor prognosis and high mortality.
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