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Updated: May 27, 2026

Expression, Detergent Solubilization, and Purification of a Membrane Transporter, the MexB Multidrug Resistance Protein
10:43

Expression, Detergent Solubilization, and Purification of a Membrane Transporter, the MexB Multidrug Resistance Protein

Published on: December 3, 2010

Multidrug resistance associated proteins in multidrug resistance

Kamlesh Sodani1, Atish Patel, Rishil J Kathawala

  • 1Department of Pharmaceutical Sciences, St. John's University, Queens, NY 11439, USA.

Chinese Journal of Cancer
|November 22, 2011
PubMed

Insights

Multidrug resistance proteins (MRPs), a key part of ATP-binding cassette (ABC) transporters, are crucial in cancer drug resistance. This review examines the functions and roles of MRP1-MRP9 in cellular resistance and in vivo.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Multidrug resistance proteins (MRPs) are a major subfamily of ATP-binding cassette (ABC) transporters.
  • The MRP family includes 13 members, with MRP1-MRP9 primarily implicated in multidrug resistance in tumor cells.
  • These transporters extrude anticancer drugs, contributing to treatment failure.

Purpose of the Study:

  • To review the physiological functions of MRP1-MRP9.
  • To explore the cellular resistance characteristics mediated by these transporters.
  • To discuss the probable in vivo roles of MRP1-MRP9.

Main Methods:

  • Literature review of existing research on MRPs.
  • Analysis of studies focusing on MRP1-MRP9 functions.
  • Synthesis of data on transporter substrates and resistance mechanisms.

Main Results:

  • MRPs are primarily lipophilic anionic transporters, transporting glutathione (GSH), glucuronate, or sulphate conjugates.
  • MRP1-MRP3 can also transport neutral organic drugs in the presence of GSH.
  • These transporters exhibit broad substrate specificity, including anticancer drugs and physiological anions.

Conclusions:

  • MRPs play a significant role in the efflux of diverse compounds, impacting drug efficacy and physiological processes.
  • Understanding MRP functions is critical for developing strategies to overcome multidrug resistance in cancer.
  • Further research into the in vivo roles of MRP1-MRP9 is warranted.

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