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Updated: May 27, 2026
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Diuretics in acute kidney injury
Sagar U Nigwekar1, Sushrut S Waikar
1Division of Nephrology, Massachusetts General Hospital, Boston, MA 02114, USA. sagarnigs@gmail.com
Seminars in Nephrology
|November 22, 2011
Summary
Loop diuretics and other agents offer limited benefits for acute kidney injury (AKI) management. Current AKI treatment remains primarily supportive, necessitating further research for effective interventions.
Area of Science:
- Nephrology
- Pharmacology
- Critical Care Medicine
Background:
- Acute kidney injury (AKI) is a prevalent condition in hospitalized patients, contributing to substantial morbidity and mortality.
- The incidence of AKI is rising, yet effective treatments remain elusive, with outcomes largely unchanged despite clinical advancements.
- Current management of AKI is predominantly supportive, lacking interventions with proven efficacy.
Purpose of the Study:
- To review the pharmacology and evidence for loop diuretics in AKI management.
- To examine evidence for other diuretic and natriuretic agents in AKI prevention and treatment.
- To provide guidance for clinical decision-making in AKI management.
Main Methods:
- Review of pharmacological properties of diuretics.
- Analysis of experimental and clinical evidence for loop diuretics in AKI.
- Evaluation of evidence for thiazide diuretics, mannitol, fenoldopam, and natriuretic peptides in AKI.
Main Results:
- Loop diuretics have not demonstrated convincing benefits in clinical studies for AKI prevention or treatment.
- Evidence for other agents like thiazide diuretics, mannitol, fenoldopam, and natriuretic peptides in AKI is also limited.
- Current clinical practice for AKI remains largely supportive.
Conclusions:
- No current diuretic or natriuretic agent has shown definitive benefits for AKI.
- Further research is needed to identify effective interventions for AKI.
- Clinical decisions in AKI management should consider the limited evidence for pharmacological agents.
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