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[Immunohistochemical study of Dlx1 and Msx1 expression during cephalic development of Dumbo and Wistar rats.
S Louryan1, N Vanmuylder, M Choa-Duterre
1Laboratoire d'anatomie, biomécanique et organogenèse, faculté de médecine, ULB, route de Lennik, 808, CP 619, 1070 Bruxelles, Belgique. Slouryan@ulb.ac.be
Abstract:
The Dumbo rat is characterized by a short snout, low ears and relative hypoplasia of maxillar and zygomatic bones. It corresponds to an autosomal recessive genotype. Previous study demonstrated a global deficit of Dlx1 and Msx1 genes expression in comparison to Wistar embryos as considered as control animals. We performed a histological study of cephalic development of Dumbo rats compared to Wistar embryos and an immunohistochemical analysis of Dlx1 and Msx1 protein expression during cephalogenesis. Our data indicate that the pattern of expression of both genes is similar in both strains, but that quantitative differences in gene expression can be the result of delayed organogenesis in Dumbo rat in comparison to Wistar. Some data about gene expressions are discussed at the light of the postulated function of Dlx1 and Msx1 in cephalic development.
