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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method
08:15

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Published on: May 22, 2019

Relationship among total kidney volume, renal function and age.

In Hyuck Gong1, Jinho Hwang, Don Kyung Choi

  • 1Department of Urology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.

The Journal of Urology
|November 22, 2011
PubMed
Summary

Kidney volume, measured by software, correlates with body size and age. This kidney size metric also shows a strong relationship with overall renal function, important for clinical practice.

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Area of Science:

  • Nephrology
  • Urology
  • Radiology

Background:

  • Kidney volume is a key indicator of renal health.
  • Understanding factors influencing kidney size is crucial for diagnosing and managing kidney diseases.

Purpose of the Study:

  • To measure kidney volume using advanced software.
  • To investigate the relationship between kidney volume and renal function.
  • To explore correlations between kidney volume and anthropometric measurements.

Main Methods:

  • Utilized a tissue segmentation tool to calculate kidney volume from CT images in 539 individuals.
  • Recorded anthropometric data (age, gender, height, weight, BMI, BSA) and serum creatinine.
  • Calculated glomerular filtration rate (GFR) using Cockcroft-Gault and MDRD equations.

Main Results:

  • Mean kidney volume was 261.3 ± 58.1 ml, with men having larger volumes than women.
  • Kidney volume significantly correlated with height, weight, BMI, BSA, and age (negatively).
  • Strong correlations were found between kidney volume and GFR (CG and MDRD equations), with both decreasing with age.

Conclusions:

  • Kidney volume is a reliable indicator that correlates with anthropometric measurements and renal function.
  • These findings are valuable for clinical applications in urology and nephrology.
  • Age-related decline in kidney volume and function highlights the importance of monitoring kidney health in aging populations.