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Fetal habituation in assisted conception.

Jolly Joy¹, Neil McClure, Peter G Hepper

¹Obstetrics and Gynaecology, Mulhouse Building, Queen's University Belfast, Belfast, BT12 6BJ, United Kingdom. jollyrobbin@hotmail.com

Early Human Development

|November 22, 2011

Summary

Fetuses conceived via assisted reproduction techniques (ART) show normal brain habituation compared to naturally conceived fetuses. However, reduced fetal response to sound later in pregnancy warrants further investigation for potential perinatal issues.

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High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo

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Published on: November 8, 2018

Area of Science:

Neuroscience
Reproductive Medicine
Fetal Development

Background:

Assisted Reproductive Technology (ART) use is increasing globally.
Concerns exist regarding neurodevelopmental outcomes in ART-conceived children.
Limited data available on prenatal neurodevelopmental assessments in ART fetuses.

Purpose of the Study:

To compare fetal brain function, specifically habituation, between ART-conceived and naturally conceived (NC) fetuses.
To assess neurodevelopmental status before birth in ART-conceived infants.

Main Methods:

A case-control study involving 20 ART and 20 NC singleton pregnancies.
Matched participants based on maternal age, parity, and smoking status.
Fetal response to auditory stimuli (250 Hz, 110 dB) assessed via ultrasound at 28, 32, and 36 weeks' gestation, measuring habituation (cessation of movement).

Main Results:

At 28 weeks, ART fetuses showed a significantly higher initial response to sound (p=0.02), but this difference diminished by 32 and 36 weeks.
A notable increase in non-responsive fetuses was observed as gestation advanced in the ART group.
No significant differences were found in habituation rates or the mean number of trials required for habituation between ART and NC groups at any gestation.

Conclusions:

ART-conceived fetuses exhibit comparable habituation to NC fetuses, indicating no apparent prenatal neurodevelopmental delay.
A declining fetal response to sound during later gestation in ART pregnancies may signal potential adverse perinatal outcomes, necessitating further research.