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Related Concept Videos

Calculating Equilibrium Concentrations02:05

Calculating Equilibrium Concentrations

Being able to calculate equilibrium concentrations is essential to many areas of science and technology—for example, in the formulation and dosing of pharmaceutical products. After a drug is ingested or injected, it is typically involved in several chemical equilibria that affect its ultimate concentration in the body system of interest. Knowledge of the quantitative aspects of these equilibria is required to compute a dosage amount that will solicit the desired therapeutic effect.
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Solubility Equilibria: Overview01:09

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Mammalian Cell Encapsulation in Alginate Beads Using a Simple Stirred Vessel
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Published on: June 29, 2017

Constitutive equations for Ca2+-alginate gels.

V Magnenet1, J Schiavi-Tritz, C Huselstein

  • 1Laboratoire Environnement Géomécanique et Ouvrages, Nancy-Université, Rue du Doyen Roubault BP 40, 54501 Vandoeuvre-lès-Nancy Cedex, France. Vincent.Magnenet@ensg.inpl-nancy.fr

Journal of the Mechanical Behavior of Biomedical Materials
|November 22, 2011
PubMed
Summary
This summary is machine-generated.

This study presents a new thermodynamic model for calcium alginate gels, accurately predicting their mechanical behavior under compression and varying crosslinking levels.

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Area of Science:

  • Biomaterials Science
  • Chemical Engineering
  • Materials Science

Background:

  • Calcium alginate gels are widely used in biomedical applications.
  • Understanding their coupled chemical and mechanical behavior is crucial for optimizing performance.
  • Existing models may not fully capture the complex interplay of these phenomena.

Purpose of the Study:

  • To develop constitutive equations for calcium alginate gels incorporating chemical-mechanical coupling.
  • To validate the model against experimental mechanical data.
  • To assess the model's predictive capability regarding crosslinking variations.

Main Methods:

  • Utilized thermodynamics of irreversible processes with internal variables.
  • Incorporated Gibbs-Duhem relation and kinetic relations for non-equilibrium forces.
  • Performed uniaxial compressive tests at various strain rates.
  • Compared model predictions with experimental results.

Main Results:

  • The developed constitutive equations showed good agreement with experimental data from uniaxial compression tests.
  • The model successfully predicted the mechanical response evolution with changes in crosslinked calcium ion concentration.
  • Demonstrated the model's ability to capture the material's behavior under different conditions.

Conclusions:

  • The thermodynamic model provides a robust framework for describing the chemo-mechanical behavior of calcium alginate gels.
  • The model offers valuable insights for designing and utilizing these gels in various applications.
  • Accurate prediction of mechanical response based on crosslinking is achievable with this thermodynamic approach.