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Updated: May 27, 2026

Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes
Published on: March 2, 2020
Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5
Jamal Krim1, Christian Grünewald, Moha Taourirte
1Laboratoire de Chimie Bioorganique et Macromoléculaire, Faculté des Sciences et Techniques-Guéliz, 40000 Marrakech, Morocco.
Abstract:
A series of novel C-5 benzimidazolyl-2'-deoxyuridines was synthesized in good yields under solvent-free conditions and microwave irradiation from 5-formyl-2'-deoxyuridine and arylenediamine derivatives in the presence of NaHSO(3) as catalyst. Their absorption and fluorescence spectra were measured. They showed intense fluorescence around 400-500nm with quantum yields between 0.3 and 0.5. All compounds studied in this work were screened for their antibacterial activities against a series of Gram positive and negative bacteria. The trifluoromethyl substituted benzimidazole derivatives showed some antibacterial activity.
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