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Related Experiment Video

Updated: May 27, 2026

Forward Genetic Approaches in Chlamydia trachomatis
09:03

Forward Genetic Approaches in Chlamydia trachomatis

Published on: October 23, 2013

Chlamydia-induced reactive arthritis: hidden in plain sight?

John D Carter1, Robert D Inman

  • 1Division of Rheumatology, Department of Internal Medicine, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., MDC 81, Tampa, FL 33612, USA. jocarter@health.usf.edu

Best Practice & Research. Clinical Rheumatology
|November 22, 2011
PubMed
Summary

Reactive arthritis, often caused by Chlamydia trachomatis, may be underdiagnosed. Increased awareness of Chlamydia-induced reactive arthritis is crucial as new treatments emerge.

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Last Updated: May 27, 2026

Forward Genetic Approaches in Chlamydia trachomatis
09:03

Forward Genetic Approaches in Chlamydia trachomatis

Published on: October 23, 2013

Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Immunology

Background:

  • Reactive arthritis (ReA) is a type of spondyloarthritis.
  • Historically, terminology for ReA has been inconsistent.
  • Chlamydia trachomatis is a leading cause of ReA.

Purpose of the Study:

  • To review current understanding of ReA, particularly Chlamydia-induced ReA.
  • To highlight the underdiagnosis of Chlamydia-induced ReA.
  • To emphasize the importance of pathogen role and host susceptibility in ReA.

Main Methods:

  • Literature review of epidemiologic, pathophysiologic, and treatment data.
  • Analysis of recent prospective epidemiologic studies.
  • Synthesis of emerging research on Chlamydia-induced ReA.

Main Results:

  • Chlamydia-induced ReA is likely underdiagnosed.
  • Chlamydia infection may be as or more critical than host factors.
  • Asymptomatic chlamydial infections may cause ReA.
  • Different ReA variants may respond uniquely to treatment.

Conclusions:

  • Chlamydia-induced ReA may be common but frequently unrecognized.
  • Enhanced disease awareness is vital for timely diagnosis and treatment.
  • Emerging treatment options offer hope for managing this condition.