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Related Concept Videos

Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
Genetic Lingo01:11

Genetic Lingo

Overview

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Related Experiment Video

Updated: May 27, 2026

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe
07:55

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

Published on: March 7, 2019

Functional genetics.

Giovanna Marchetti1, Mirko Pinotti, Barbara Lunghi

  • 1Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy.

Thrombosis Research
|November 22, 2011
PubMed
Summary

Genetic variations impact biological function, necessitating advanced methods. This review highlights intermediate phenotypes and transcriptomics to understand genetic links to diseases like cardiovascular disorders.

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Last Updated: May 27, 2026

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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

Area of Science:

  • Genetics and Medicine
  • Genomic Medicine
  • Molecular Biology

Background:

  • Understanding genetic variations is crucial for both normal and abnormal biological functions.
  • The vast number of human genomic sequences and variations demands efficient analysis methods.
  • Identifying functional correlates of genetic variations is a significant challenge in biology and medicine.

Purpose of the Study:

  • To review the importance of intermediate phenotypes in genetic studies.
  • To discuss transcriptomic approaches in diseased cells for understanding gene expression.
  • To explore how sequence variations affect mRNA splicing and protein multimerization.

Main Methods:

  • Assessment of well-defined intermediate phenotypes.
  • Setup of transcriptomic approaches in diseased cells.
  • Analysis of sequence variations modulating mRNA splicing and protein multimerization.

Main Results:

  • Intermediate phenotypes and transcriptomics provide molecular insights into genomic associations.
  • Sequence variations can alter gene expression through mRNA splicing and protein interactions.
  • These findings offer a basis for developing new diagnostic and therapeutic strategies.

Conclusions:

  • Elucidating the functional impact of genetic variations is key to advancing personalized medicine.
  • Focusing on intermediate phenotypes and transcriptomic data can reveal disease mechanisms.
  • This approach holds promise for novel interventions, particularly in cardiovascular disorders.