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Updated: May 27, 2026
04:56
In Vivo Electrophysiological Measurement of the Rat Ulnar Nerve with Axonal Excitability Testing
Published on: February 6, 2018
[Original articles on axonal neuropathy in 2010].
1Centre de référence des maladies neuromusculaires et de la SLA, CHU de La-Timone, 264, rue Saint-Pierre, 13385 Marseille, France. shahram.attarian@ap-hm.fr
Revue Neurologique
|November 22, 2011
Summary
Diabetic sensorimotor polyneuropathy diagnosis can be overestimated. Long-term Metformin use may worsen neuropathy by causing vitamin B12 malabsorption, while vitamin E shows neuroprotection against cisplatin toxicity.
Area of Science:
- Neurology
- Endocrinology
- Toxicology
Context:
- Chronic sensorimotor axonal neuropathy is a significant clinical concern, with diagnostic variability impacting incidence rates.
- Long-term Metformin use in type 2 diabetes is linked to vitamin B12 malabsorption, potentially exacerbating peripheral neuropathy.
- Cisplatin-induced neurotoxicity and metallosis from hip arthroplasty are other contributing factors to neurological disturbances.
Purpose:
- To review recent literature on chronic sensorimotor axonal neuropathy.
- To highlight iatrogenic causes and potential neuroprotective agents.
- To assess the impact of neuropathy on patient safety and quality of life.
Summary:
- Clinical diagnosis of diabetic sensorimotor polyneuropathy is often variable and may overestimate incidence.
- Metformin-associated vitamin B12 malabsorption can worsen peripheral neuropathy in diabetic patients.
- Vitamin E may offer neuroprotection against cisplatin toxicity; metallosis and electrical stimulation effects are also discussed.
- Neuropathy patients exhibit higher rates of motor vehicle accidents and driving discomfort.
Impact:
- Improved diagnostic accuracy for diabetic sensorimotor polyneuropathy is needed.
- Awareness of Metformin's side effects can guide clinical management.
- Further research into neuroprotective strategies and patient safety is warranted.
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