Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Drp1-driven fragmentation of scleral mitochondria promotes myopia development.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Thyroid-stimulating hormone receptor mediates peripheral-central neuroimmune crosstalk in autoimmune thyroid diseases.

BMC medicine·2026
Same author

RDINet: A novel dynamic mapping model integrating radiomics and deep learning for predicting treatment response in thyroid eye disease.

Digital health·2026
Same author

Comparative Proteomic Profiling of Microdissected Spindle and Epithelioid Uveal Melanoma Subtypes.

Investigative ophthalmology & visual science·2026
Same author

Integrating spatial and single-cell transcriptomics analysis reveals MYCN-UBE2C-TFRC signaling endows ferroptosis resistance in neuroectodermal tumors.

Science China. Life sciences·2026
Same author

The global cancer crisis: a review of growing burden, deepening inequality and initiatives for prevention and early detection.

Ecancermedicalscience·2026

Related Experiment Video

Updated: May 27, 2026

Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo
09:49

Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo

Published on: February 23, 2024

A functional polymer designed for bone tissue engineering.

Zhengwei You1, Xiaoping Bi, Xianqun Fan

  • 1Department of Bioengineering, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, PA 15261, USA.

Acta Biomaterialia
|November 22, 2011
PubMed
Summary
This summary is machine-generated.

Researchers developed a new functionalizable polymer, poly(fumaroyl bioxirane) maleate (PFM), for bone tissue engineering. PFM supports osteoblast growth and has mechanical properties similar to bone, offering potential for regenerative medicine.

More Related Videos

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

Related Experiment Videos

Last Updated: May 27, 2026

Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo
09:49

Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo

Published on: February 23, 2024

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Synthetic polymers often lack the necessary biological and chemical functionalities for effective cell-material interactions.
  • Controlling the biointerface is crucial for applications like tissue engineering, but current synthetic polymers have limitations.
  • Polymers with accessible functional groups are needed for facile modifications to tailor biointerfacial properties.

Purpose of the Study:

  • To create a novel functionalizable polymer, poly(fumaroyl bioxirane) maleate (PFM), for bone tissue engineering applications.
  • To incorporate three distinct free functional groups (hydroxyl, carboxyl, alkenyl) into PFM for versatile modification.
  • To evaluate the physical, mechanical, and biological properties of PFM for its potential in bone regeneration.

Main Methods:

  • Synthesis of poly(fumaroyl bioxirane) maleate (PFM) through a two-step process.
  • Characterization of PFM's mechanical properties, including strain-dependent moduli and comparison to native bone.
  • In vitro assessment of PFM's biocompatibility using rat calvarial osteoblasts, evaluating adhesion, spreading, proliferation, maturity, and alkaline phosphatase activity.

Main Results:

  • PFM was successfully synthesized in two steps and possesses three free functional groups.
  • PFM exhibited strain-dependent mechanical moduli comparable to native bone.
  • PFM demonstrated excellent support for osteoblast adhesion, spreading, proliferation, and maturity, with significantly higher alkaline phosphatase activity compared to polystyrene.

Conclusions:

  • Poly(fumaroyl bioxirane) maleate (PFM) is a promising functionalizable polymer for bone tissue engineering.
  • The inherent functionalities and tunable properties of PFM make it suitable for controlling cell-material interactions.
  • PFM offers a versatile platform for advancing bone tissue engineering and regenerative medicine strategies.