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Related Experiment Video

Updated: May 27, 2026

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection

Published on: August 23, 2022

Pathogenic alteration in severe burn wounds.

Yang Fu¹, Bing Xie, DaoFeng Ben

¹Burn Center, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.

Burns : Journal of the International Society for Burn Injuries

|November 22, 2011

Summary

This summary is machine-generated.

This 12-year study tracked bacterial changes in severe burn wounds, finding Staphylococcus aureus and Acinetobacter baumannii increased over time. Antibiotic resistance patterns shifted, with Vancomycin remaining effective against Staphylococcus aureus.

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Area of Science:

Infectious Diseases
Microbiology
Burn Care

Background:

Bacterial infections are a major complication in severe burn patients.
Understanding temporal trends in bacterial pathogens and their resistance is crucial for effective treatment.
Local microbial epidemiology in burn centers can vary significantly.

Purpose of the Study:

To analyze the 12-year trend of bacterial alterations and resistance in severe burn wounds.
To identify shifts in the prevalence of common bacterial pathogens over time.
To evaluate antibiotic sensitivity patterns in relation to identified bacterial changes.

Main Methods:

Retrospective analysis of microbiological data from severe burn patients (1998-2009).
Identification and quantification of 3615 microbial isolates.
Comparison of bacterial species ratios and antibiotic resistance rates between two 6-year periods (1998-2003 and 2004-2009).

Main Results:

Staphylococcus aureus (38.2%) and Acinetobacter baumannii (16.2%) were the most frequent pathogens.
S. aureus and A. baumannii prevalence increased significantly between weeks 1-8 of hospitalization.
Vancomycin demonstrated consistent sensitivity against Staphylococcus aureus, including MRSA.

Conclusions:

Bacterial composition in severe burn wounds evolves over the course of hospitalization.
Acinetobacter baumannii infections often manifest later (around 4 weeks post-admission).
Antibiotic usage patterns likely influence observed trends in bacterial resistance and prevalence.