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Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Mitochondria

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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Related Experiment Video

Updated: May 27, 2026

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Aging-kb: a knowledge base for the study of the aging process.

Kevin G Becker¹, Karen A Holmes, Yongqing Zhang

¹Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, United States. beckerk@grc.nia.nih.gov

Mechanisms of Ageing and Development

|November 22, 2011

Summary

This summary is machine-generated.

AGING-kb is a new public knowledge base designed to integrate aging research data and theory. It features an intuitive tree hierarchy and a collaborative wiki to clarify the complexities of the aging process.

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Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

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Published on: June 3, 2020

Area of Science:

Gerontology
Bioinformatics
Knowledge Management

Background:

Integrating diverse aging data with existing theories presents a significant challenge.
Disseminating complex aging information to the scientific community requires accessible platforms.

Purpose of the Study:

To present fundamental aspects of aging research through a structured knowledge base.
To facilitate the integration of multi-modal data within the context of aging science.
To provide an intuitive interface for understanding the complexities of the aging process.

Main Methods:

Development of AGING-kb, a public knowledge base.
Implementation of a dynamic tree hierarchy (Aging-kb tree) for organizing aging research terms.
Creation of a specialized wiki (Aging Wiki) for expert definitions and community contributions.

Main Results:

AGING-kb offers a two-part structure: the Aging-kb tree and the Aging Wiki.
The Aging-kb tree provides a logical, hierarchical view of aging research areas.
The Aging Wiki enables collaborative definition and documentation of aging concepts.

Conclusions:

AGING-kb simplifies the conceptualization and dissemination of aging research.
The knowledge base enhances understanding of relationships between different aging research domains.
This resource promotes community participation in defining and refining aging terminology.