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Density spectral array analysis of SREDA during EEG-video monitoring
Robert P Carson1, Bassel W Abou-Khalil
1Division of Epilepsy, Department of Neurology, Vanderbilt University, Nashville, TN, USA.
Objective:
To report the temporal pattern of subclinical rhythmic electrographic discharge of adults (SREDA) and its response to lorazepam during EEG-video monitoring.
Methods:
We recorded EEG-video for 3 days in a patient with SREDA, who was previously misdiagnosed with generalized epilepsy. Because SREDA had a very prominent signature on density spectral array (DSA), we used DSA to study the pattern of SREDA over the diurnal cycle, and the response to intravenous lorazepam.
Results:
SREDA occurred in both waking and sleep, but tended to occur in single bursts in waking and in longer clusters during sleep. Lorazepam suppressed SREDA.
Conclusions:
The temporal pattern of SREDA varies during the sleep-wake cycle. Lorazepam appears to suppress SREDA.
Significance:
Response to lorazepam cannot distinguish SREDA from electrographic seizure activity.
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