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Updated: May 27, 2026
09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
Nanoparticles for intracellular-targeted drug delivery.
Cristiana S O Paulo1, Ricardo Pires das Neves, Lino S Ferreira
1CNC-Center of Neurosciences and Cell Biology, University of Coimbra, Portugal.
Nanotechnology
|November 22, 2011
Summary
Nanoparticles (NPs) offer promising intracellular drug delivery for cancer and immune therapies. Precise targeting of NPs to specific cell locations enhances drug efficacy and minimizes side effects.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Pharmacology
Background:
- Nanoparticles (NPs) are increasingly utilized for intracellular drug delivery.
- Initial research focused on DNA delivery, with growing interest in other molecules.
- Modulating cell activity requires targeted delivery to specific cellular organelles.
Purpose of the Study:
- To review recent advancements in nanoparticle-mediated intracellular delivery.
- To highlight the targeted delivery of short interference RNA, proteins, and small molecules.
- To discuss the importance of spatial control for enhanced therapeutic effects and reduced side effects.
Main Methods:
- Literature review of current research on NP-based intracellular delivery.
- Analysis of strategies for targeting NPs to specific cellular locations.
- Examination of therapeutic molecules delivered via NPs.
Main Results:
- Nanoparticles show significant promise for delivering anticancer and immunomodulatory drugs.
- Intracellular delivery of short interference RNA, proteins, and small molecules is advancing.
- Targeted delivery to organelles is crucial for optimizing drug effects.
Conclusions:
- Spatial control in intracellular delivery using NPs is key to modulating cell activity effectively.
- Precise NP targeting can lead to desired drug effects with minimized side effects.
- This approach opens new possibilities for targeted therapies.
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