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Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

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Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
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Published on: November 23, 2014

Emerging technologies for enabling proangiogenic therapy.

Rituparna Sinha Roy1, Bhaskar Roy, Shiladitya Sengupta

  • 1Department of Biological and Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur Campus, P O BCKV Campus Mail Office, West Bengal 741252, India. rituparna@iiserkol.ac.in

Nanotechnology
|November 22, 2011
PubMed
Summary
This summary is machine-generated.

Therapeutic angiogenesis uses protein engineering and biomaterials to stabilize growth factors for treating ischemic diseases. This approach aims for sustained delivery of active proteins to improve outcomes for patients with vascular conditions.

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • Ischemic diseases represent a major global health burden, causing significant mortality and morbidity.
  • Therapeutic angiogenesis offers a promising strategy to combat ischemic pathologies.
  • Current limitations include the instability of angiogenic proteins and challenges in their sustained delivery.

Purpose of the Study:

  • To explore protein engineering strategies for developing stabilized proangiogenic proteins.
  • To review biomaterial technologies for sustained delivery of angiogenic growth factors.
  • To enhance therapeutic outcomes for ischemic diseases through improved angiogenic therapies.

Main Methods:

  • Protein engineering techniques to enhance the stability and activity of angiogenic factors.
  • Development and application of advanced biomaterial systems for controlled drug release.
  • In vitro and in vivo models to evaluate the efficacy of stabilized proteins and delivery systems.

Main Results:

  • Engineered proteins demonstrate improved stability and prolonged biological activity.
  • Biomaterial scaffolds facilitate sustained release of functional growth factors at target sites.
  • Combined strategies show potential for enhanced neovascularization in ischemic tissues.

Conclusions:

  • Protein engineering and biomaterial-based delivery systems are crucial for advancing therapeutic angiogenesis.
  • These integrated approaches hold significant promise for treating ischemic diseases.
  • Further research can optimize these strategies for clinical translation.