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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

DOCUMENT: a system for classifying drug-related problems in community pharmacy.

Mackenzie Williams¹, Gregory M Peterson, Peter C Tenni

¹School of Pharmacy, University of Tasmania, Private Bag 26, Hobart, TAS, 7001, Australia. Mackenzie.Williams@utas.edu.au

International Journal of Clinical Pharmacy

|November 22, 2011

Summary

Australian community pharmacists use the DOCUMENT system to record drug-related problems (DRPs) and clinical interventions. The system helps identify common issues like drug selection and educational problems, improving patient care.

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Area of Science:

Pharmaceutical practice
Health informatics
Medication safety

Background:

Drug-related problems (DRPs) pose a significant burden on the Australian healthcare system.
Community pharmacists are strategically positioned to identify, prevent, and resolve DRPs.
Existing documentation methods for DRPs and interventions may lack efficiency and ease of use.

Purpose of the Study:

To develop and validate an accessible documentation system for pharmacists to classify and record DRPs.
To investigate the frequency and nature of clinical interventions performed by Australian community pharmacists.
To assess the clinical significance of pharmacist interventions.

Main Methods:

The DOCUMENT classification system was developed and validated through pilot studies.
The system was integrated into software deployed in 185 Australian community pharmacies.
A 12-week trial recorded DRPs and clinical interventions across over 2 million prescriptions.

Main Results:

A total of 5,948 DRPs and interventions were documented.
Interventions most frequently addressed drug selection (30.7%) and educational issues (23.7%).
Pharmacists provided an average of 1.6 recommendations per intervention, with 42.6% deemed clinically significant.

Conclusions:

The DOCUMENT system proved to be a user-friendly tool for pharmacists.
The trial enhanced understanding of clinical intervention frequency and nature in community pharmacy.
Findings supported the national implementation of the DOCUMENT system.