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Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

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Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates

Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates

Published on: June 17, 2016

Engineering approaches toward deconstructing and controlling the stem cell environment.

Faramarz Edalat¹, Hojae Bae, Sam Manoucheri

¹Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, Room 252, 65 Landsdowne Street, Cambridge, MA 02139, USA.

Annals of Biomedical Engineering

|November 22, 2011

Summary

This summary is machine-generated.

Nano- and microengineered materials are revolutionizing stem cell therapies by mimicking the stem cell niche. These technologies enable better understanding, construction, and application of stem cells for tissue regeneration.

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Area of Science:

Biomaterials Science
Regenerative Medicine
Stem Cell Biology

Background:

Stem cell therapeutics are crucial for tissue engineering and regenerative medicine.
The stem cell niche (microenvironment) regulates stem cell behavior.
Current methods cannot fully replicate the stem cell niche's complexity.

Purpose of the Study:

To explore how nano- and microengineered materials can overcome limitations in stem cell niche recapitulation.
To highlight advances in using these materials for stem cell engineering.
To discuss future applications in regenerative medicine.

Main Methods:

Deconstructing the stem cell niche using engineered materials to study individual components.
Constructing biomimetic, tissue-like structures that resemble the native niche.
Utilizing these engineered systems for stem cell transplantation and activation.

Main Results:

Engineered materials provide novel ways to understand stem cell niche interactions.
These technologies facilitate the creation of complex, functional tissue constructs.
Applications include enhanced stem cell transplantation and activation for regeneration.

Conclusions:

Nano- and microtechnologies are essential tools for advancing stem cell engineering.
These approaches offer innovative strategies for tissue regeneration and treating diseases.
Further development holds significant promise for future therapeutic applications.