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Updated: May 27, 2026

Quantifiable and Inexpensive Cell-Free Fluorescent Method to Confirm the Ability of Novel Compounds to Chelate Iron
Published on: February 23, 2024
Preparation and investigation of bioactive transferrin-iron complexes formed with different synergistic anions
Judit Gálicza1, Andrea Vargová, Viktor Sándor
1Applied Chemistry and Material Science, Politehnica University of Bucharest, 010737, Bucharest, Romania. galiczajudit@yahoo.com
Abstract:
Human serum transferrin has a potential for drug-delivery systems. Oxalate and aziridine-carboxylate was conjugated to serum transferrin in order to transport into the targeted cancer cells via transferrin-receptor mediated endocytosis. Capillary zone electrophoresis and capillary isoelectric focusing were used to analyze the effectiveness of complexation reactions. The electropherograms show the differences between iron-free- and iron-complexed molecular forms of human serum transferrin. The iron-complexed transferrin sample containing the different anions as synergistic complexing agents were characterized by different electrophoretic parameters.
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