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Number of children is associated with plasma CRP levels

Jaroslav A Hubáček1, Ivana Králová-Lesná, Věra Lánská

  • 1Institute for Clinical and Experimental Medicine, Prague, Czech Republic. jahb@ikem.cz

Neuro Endocrinology Letters
|November 22, 2011
PubMed

Insights

Having more children is linked to higher C-reactive protein (CRP) levels. This association may relate to increased stress factors in individuals with larger families.

Area of Science:

  • Biomedical Science
  • Human Health

Background:

  • C-reactive protein (CRP) is a liver-produced acute-phase protein.
  • Elevated CRP levels are linked to infection and over 100 other conditions, including socioeconomic factors.

Purpose of the Study:

  • To investigate the association between the number of children and plasma C-reactive protein (CRP) levels.
  • To determine if family size influences a key inflammation marker.

Main Methods:

  • A population-based study of 2,426 adults.
  • Plasma C-reactive protein (CRP) analyzed using high-sensitivity assay (hsCRP).
  • Participants categorized into groups based on the number of children (0, 1, 2, 3, 4+).

Main Results:

  • Individuals with more children exhibited significantly higher plasma hsCRP levels.
  • A significant trend (p < 0.001) showed increasing hsCRP with an increasing number of children.
  • The association suggests a potential link between family size and inflammation markers.

Conclusions:

  • Higher numbers of children are significantly associated with elevated plasma CRP levels.
  • Individuals with more children or a low number of children showed higher CRP compared to childless individuals.
  • Findings may reflect stress-related pathways influencing CRP in larger families.
Abstract

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