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Viral Structure

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Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.

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Updated: May 27, 2026

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes

Published on: September 27, 2014

A shared structural solution for neutralizing ebolaviruses.

João M Dias¹, Ana I Kuehne, Dafna M Abelson

¹Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.

Nature Structural & Molecular Biology

|November 22, 2011

Summary

This summary is machine-generated.

A new antibody, 16F6, neutralizes the lethal Sudan virus by targeting its glycoprotein. This discovery offers a potential therapeutic strategy against Ebolavirus infections.

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Published on: December 29, 2015

Area of Science:

Virology
Immunology
Structural Biology

Background:

Sudan virus, an Ebolavirus species, poses a significant lethal threat.
No effective monoclonal antibodies were previously known to neutralize Sudan virus.

Purpose of the Study:

To identify and characterize a neutralizing antibody against Sudan virus.
To elucidate the structural basis of Sudan virus neutralization by antibodies.

Main Methods:

Description of antibody 16F6 isolation and characterization.
Determination of the crystal structure of Sudan virus glycoprotein in complex with antibody 16F6.

Main Results:

Antibody 16F6 was found to neutralize Sudan virus.
The structure revealed that 16F6 binds to the viral glycoprotein.
The epitope recognized by 16F6 overlaps with that of antibody KZ52, another antibody targeting the GP(1,2) core.
Both 16F6 and KZ52 antibodies neutralize at a post-internalization step, likely during fusion.

Conclusions:

Antibody 16F6 represents a novel neutralizing agent against Sudan virus.
The overlapping epitope suggests a critical vulnerability in the Ebolavirus glycoprotein.
Understanding this neutralization mechanism may inform the development of broader Ebolavirus therapeutics.