Related Experiment Video
Updated: May 27, 2026

Application of Chronic Stimulation to Study Contractile Activity-induced Rat Skeletal Muscle Phenotypic Adaptations
Published on: January 25, 2018
In sickness and in health: the widespread application of creatine supplementation
Bruno Gualano1, Hamilton Roschel, Antonio Herbert Lancha
1School of Physical Education and Sport, University of Sao Paulo, Av Mello de Moraes, 65 Butantã, Sao Paulo, Brazil. gualano@usp.br
Abstract:
There is an extensive and still growing body of the literature supporting the efficacy of creatine (Cr) supplementation. In sports, creatine has been recognized as the most effective nutritional supplement in enhancing exercise tolerance, muscle strength and lean body mass. From a clinical perspective, the application of Cr supplementation is indeed exciting. Evidences of benefits from this supplement have been reported in a broad range of diseases, including myopathies, neurodegenerative disorders, cancer, rheumatic diseases, and type 2 diabetes. In addition, after hundreds of published studies and millions of exposures creatine supplementation maintains an excellent safety profile. Thus, we contend that the widespread application of this supplement may benefit athletes, elderly people and various patient populations. In this narrative review, we aimed to summarize both the ergogenic and therapeutic effects of Cr supplementation. Furthermore, we reviewed the impact of Cr supplementation on kidney function.
More Related Videos
09:40Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
Published on: January 19, 2017
08:31Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models
Published on: December 17, 2021
Related Concept Videos
Exercise and Muscle Performance
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Chronic Kidney Disease III: Interprofessional Care
Cellular Adaptation II: Hypertrophy
Muscle Recovery and Fatigue
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
Energy Supply for Muscle Contraction