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CNTRICS imaging biomarkers final task selection: Long-term memory and reinforcement learning.

John D Ragland1, Neal J Cohen, Roshan Cools

  • 1Department of Psychiatry and Behavioral Sciences, University of California at Davis Imaging Research Center, Sacramento, CA 95817, USA. jdragland@ucdavis.edu

Schizophrenia Bulletin
|November 22, 2011
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Summary

Functional imaging shows promise for schizophrenia research. The Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative identified key long-term memory paradigms for biomarker development.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Psychiatry

Background:

  • Schizophrenia is characterized by cognitive and emotional deficits.
  • Functional imaging offers potential biomarkers for understanding these deficits.
  • Identifying reliable biomarkers is crucial for treatment research.

Framework:

  • The Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative focuses on long-term memory (LTM) constructs.
  • Key LTM domains selected include item encoding/retrieval, relational encoding/retrieval, and reinforcement learning.
  • These constructs guide the nomination of promising functional imaging paradigms.

Implementation:

  • The third CNTRICS biomarkers meeting convened to discuss nominated paradigms.
  • A review panel reached a consensus on paradigms recommended for translational development.
  • Four specific functional imaging paradigms were selected for immediate development.

Implications:

  • Selected paradigms underwent detailed description, including task specifics.
  • Evaluation criteria included construct validity, sensitivity to manipulation, animal models, psychometrics, and effects of schizophrenia.
  • This work aims to advance the development of functional imaging biomarkers for schizophrenia treatment research.