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Published on: October 20, 2020
Application of activity-based protein profiling to the study of microbial pathogenesis
William P Heal1, Edward W Tate
1Department of Chemistry, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK.
None:
Activity-based protein profiling (ABPP) is a powerful technology for the dissection of dynamic and complex enzyme interactions. The mechanisms involved in microbial pathogenesis are an example of just such a system, with a plethora of highly regulated enzymatic interactions between the infecting organism and its host. In this review we will discuss some of the cutting-edge applications of ABPP to the study of bacterial and parasitic pathogenesis and virulence, with an emphasis on Clostridium difficile, methicillin-resistant Staphylococcus aureus, quorum sensing, and malaria.
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