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Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)
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Mouse Phenome Database (MPD).

Terry P Maddatu1, Stephen C Grubb, Carol J Bult

  • 1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

Nucleic Acids Research
|November 22, 2011
PubMed
Summary
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The Mouse Phenome Database (MPD) centralizes mouse strain data for translational research. It offers standardized data and tools to aid researchers in selecting mouse models and exploring genotype-phenotype relationships for human health studies.

Area of Science:

  • Genomics
  • Translational Medicine
  • Bioinformatics

Background:

  • The Mouse Phenome Project initiated a decade ago to standardize mouse phenotyping.
  • A central public database, the Mouse Phenome Database (MPD), was established to collect this data.
  • The laboratory mouse is crucial for translational research in human health and disease.

Purpose of the Study:

  • To present improvements and updates to the Mouse Phenome Database (MPD).
  • To highlight new tools and features for data navigation and mining.
  • To report the acquisition of new phenotypic, genotypic, and gene expression data.

Main Methods:

  • Data collection through voluntary contributions and public sources.
  • Standardization of phenotyping conditions and data collection.

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Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson's Disease Model
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  • Development of tools for data mining, navigation, and hypothesis testing.

    • Main Results:

    • MPD houses extensive strain characteristics data for research applications.
    • The database facilitates the selection of appropriate mouse strains.
    • MPD provides a platform for discovering genotype-phenotype relationships and analyzing intervention effects.

    Conclusions:

    • MPD is a valuable resource for the research community, supporting translational studies.
    • Ongoing updates enhance MPD's utility for selecting mouse models and advancing research.
    • The database supports hypothesis generation and testing in mouse models relevant to human disease.