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Updated: May 27, 2026

Reconstitution of Actin-Based Motility with Commercially Available Proteins
Published on: October 28, 2022
From filopodia to synapses: the role of actin-capping and anti-capping proteins
Elisabetta Menna1, Giuliana Fossati, Giorgio Scita
1Department of Medical Pharmacology and CNR Institute of Neuroscience, University of Milan, Milano, Italy.
Abstract:
Actin-capping and anti-capping proteins are crucial regulators of actin dynamics. Recent studies have indicated that these proteins may be heavily involved in all stages of synaptogenesis, from the emergence of filopodia, through neuritogenesis and synaptic contact stabilization, to the structural changes occurring at the synapse during potentiation phenomena. In this review, we focus on recent evidence pointing to an active role of actin-capping and anti-capping proteins in orchestrating the processes controlling neuronal connectivity and plasticity.
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