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Functional Calcium Imaging in Developing Cortical Networks
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Published on: October 22, 2011

Electrical activity patterns and the functional maturation of the neocortex.

Werner Kilb1, Sergei Kirischuk, Heiko J Luhmann

  • 1Institute of Physiology and Pathophysiology, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, Mainz, Germany.

The European Journal of Neuroscience
|November 23, 2011
PubMed
Summary

Early spontaneous neuronal activity in sensory areas shapes brain development. Disruptions in these patterns can impact the formation of cortical layers and networks.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Computational Neuroscience

Background:

  • Spontaneous neuronal network activity is observed in early sensory neocortical development.
  • These patterns originate from cortical, subcortical, or peripheral networks.
  • Early activity influences critical developmental processes like neurogenesis and network formation.

Purpose of the Study:

  • To review the origins of early electrical activity patterns in sensory neocortical areas.
  • To explore the functional implications of these patterns on developing cortical networks.
  • To understand how early neuronal activity shapes corticogenesis.

Main Methods:

  • Review of in vitro and in vivo experimental data.
  • Analysis of spontaneous and evoked neuronal activity.
  • Examination of developmental processes influenced by neuronal activity.

Main Results:

  • Early activity patterns can be local or large-scale, originating from various brain regions.
  • The thalamus and neocortical subplate relay and amplify sensory input.
  • Altered early neuronal patterns are linked to developmental abnormalities in cortical structures.

Conclusions:

  • Early spontaneous and evoked neuronal activity is crucial for normal corticogenesis.
  • Understanding the origins and functions of early activity patterns is key to comprehending brain development.
  • Disturbances in early network activity may lead to long-term neurological consequences.