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Alternations of phospholipid profile in placenta of streptozotocin-induced diabetic rat

Mina Hasegawa1, Katsuhiro Tanaka, Masayuki Komori

  • 1Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan.

Congenital Anomalies
|November 23, 2011
PubMed

Phospholipids have important roles in many biological processes, but their role in fetal malformation in pregnancy in diabetes is unclear. Metabolic fingerprinting of placental phospholipids in pregnant streptozotocin-induced type 1 diabetic rats was performed using Fourier transform-ion cyclotron resonance mass spectrometry. Some of the fetuses from the pregnant diabetic rats exhibited ventricular septal defects. Alterations of phospholipid compositions in the diabetic rat placenta were detected. We suggest that these changes in phospholipids in the diabetic placenta might be involved in development of fetal malformation in a type 1 diabetic pregnancy.

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