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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
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Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
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Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

Updated: May 27, 2026

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
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Mesna-induced photodistributed dermatosis.

C Y Lin1, M Keefe

  • 1Department of Dermatology, Canterbury District Health Board, Christchurch, New Zealand. cyf.trust@gmail.com

Clinical and Experimental Dermatology
|November 23, 2011
PubMed
Summary
This summary is machine-generated.

A man developed a sun-sensitive rash after taking 2-mercaptoethane sulfonate sodium (mesna) for cyclophosphamide-induced hemorrhagic cystitis. The rash resolved after stopping mesna, marking the first reported case of mesna-induced photodistributed dermatosis.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Internal Medicine

Background:

  • A 41-year-old male patient with a history of Wegener granulomatosis was undergoing treatment for cyclophosphamide-induced hemorrhagic cystitis.
  • The patient had been on a stable dose of cyclophosphamide (150 mg daily) for three years.

Observation:

  • One month after initiating 2-mercaptoethane sulfonate sodium (mesna), the patient developed a photodistributed eruption.
  • The rash appeared in areas exposed to sunlight.

Findings:

  • Complete resolution of the photodistributed dermatosis was observed within eight weeks of discontinuing mesna.
  • This case represents the first documented instance of mesna-induced photodistributed dermatosis.

Implications:

  • Early identification of mesna-induced photodistributed dermatosis is crucial for prompt management.
  • Discontinuation of mesna should be considered in patients presenting with similar dermatological reactions.
  • Alternative treatments for hemorrhagic cystitis may be necessary in such cases.