The CD4C/HIV(Nef)transgenic model of AIDS
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Updated: May 27, 2026

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Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
Published on: September 11, 2019
1Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada. paul.jolicoeur@ircm.qc.ca
Current HIV Research
|November 23, 2011
Abstract:
CD4C/HIVNef Tg mice express HIV-1 Nef in relevant target cells through the regulatory sequences of the human CD4 gene. These mice develop a severe disease showing many characteristics of human AIDS. A summary of the results obtained with these Tg mice is presented.

