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Renin-angiotensin system blockade and reduction of cardiovascular risk: future perspectives

Alejandro de la Sierra1

  • 1Department of Internal Medicine, Hospital Mutua Terrassa, Plaza Dr Robert 5, 08021 Terrassa, Spain. adelasierra@mutuaterrassa.es

Expert Review of Cardiovascular Therapy
|November 23, 2011
PubMed

Insights

Renin-angiotensin system blockers offer cardiovascular benefits but residual risk remains. New strategies are needed to further reduce cardiovascular disease risk in patients on these therapies.

Area of Science:

  • Cardiology
  • Pharmacology
  • Nephrology

Background:

  • Renin-angiotensin system (RAS) blockers, including ACE inhibitors and ARBs, are beneficial in cardiovascular disease.
  • These drugs lower blood pressure, prevent subclinical disease markers like microalbuminuria, and reduce events in patients with lesions.
  • RAS blockers prolong survival in patients with clinical disease or organ dysfunction.

Purpose of the Study:

  • To review strategies for reducing residual cardiovascular disease risk in patients treated with RAS blockers.
  • To explore options beyond current RAS blockade for enhanced cardiovascular protection.

Main Methods:

  • Literature review of studies on cardiovascular disease prevention and risk reduction.
  • Analysis of therapeutic strategies aimed at improving outcomes in patients on RAS blockers.

Main Results:

  • Despite benefits, residual cardiovascular risk persists in patients treated with RAS blockers.
  • Several strategies can potentially lower this residual risk.

Conclusions:

  • Primary prevention in healthy individuals is crucial.
  • Stricter therapeutic goals and comprehensive risk factor control are necessary.
  • Enhanced RAS blockade and combination therapies with synergistic mechanisms may further reduce cardiovascular risk.

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