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C-type natriuretic peptide forms in adult hyperthyroidism: correlation with thyroid hormones and markers of bone

Belinda J Schouten1, Timothy C Prickett, Penelope J Hunt

  • 1Department of Endocrinology, Christchurch Hospital, Christchurch, New Zealand.

Clinical Endocrinology
|November 23, 2011
PubMed

Insights

Thyroid hormones (TH) influence C-type natriuretic peptide (CNP) levels in adults, similar to children. Restoring euthyroidism in hyperthyroid adults affects CNP and bone turnover markers, suggesting CNP

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Cardiovascular Peptides

Background:

  • Plasma C-type natriuretic peptide (CNP) levels correlate with linear growth in children.
  • In hyperthyroid children, CNP and thyroid hormones (TH) decrease in parallel as euthyroidism is restored.
  • The impact of TH on CNP after skeletal maturity is not well understood.

Purpose of the Study:

  • To investigate the effect of normalizing thyroid hormone levels on plasma CNP forms.
  • To assess changes in bone turnover markers (BTMs) in hyperthyroid adults during treatment.
  • To determine the relationship between CNP, TH, and BTMs in adults.

Main Methods:

  • Prospective observational study of 20 adults with acquired hyperthyroidism.
  • Measurement of plasma C-type natriuretic peptide (CNP), amino-terminal propeptide of CNP (NTproCNP), thyroid hormones (TH), and bone turnover markers (BTMs).
  • Serial measurements were taken before and during 6 months of carbimazole treatment, with correlation analyses performed.

Main Results:

  • Plasma CNP and NTproCNP levels significantly correlated with TH at baseline.
  • Decreases in CNP forms paralleled the reduction in TH during treatment.
  • Significant associations were observed between CNP forms and bone resorption marker CTx.

Conclusions:

  • C-type natriuretic peptide (CNP) production is responsive to thyroid hormones (TH) in adult tissues beyond cartilage.
  • The temporal relationship between CNP and bone resorption markers suggests a role for CNP in adult bone remodeling.
  • Thyroid hormone status impacts both CNP and bone turnover in adults.
Abstract

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