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[Urinary tract infections: antibiotic resistance and clinical follow up]

C de Lucas Collantes1, J Cela Alvargonzalez, A M Angulo Chacón

  • 1Servicio de Pediatría, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España. mcdelucas@yahoo.es

Anales De Pediatria (Barcelona, Spain : 2003)
|November 23, 2011
PubMed

Insights

Urinary tract infection (UTI) treatment requires understanding local antibiotic resistance. This study found E. coli highly sensitive to fosfomycin and cefotaxime, crucial for empirical UTI treatment in children.

Area of Science:

  • Pediatric infectious diseases
  • Microbiology
  • Antibiotic resistance

Context:

  • Empirical antibiotic treatment is standard for urinary tract infections (UTIs).
  • Determining local antibiotic resistance patterns is crucial for effective initial management.
  • Acute pyelonephritis diagnosis requires ruling out renal scarring, a potential complication.

Purpose:

  • To analyze antibiotic susceptibility patterns of common urinary pathogens in children.
  • To assess the incidence of renal scarring following UTIs in pediatric patients.

Summary:

  • A retrospective study analyzed UTI cases in children under 14 from 2009-2010.
  • E. coli was the most frequent pathogen (80%), showing high in vitro susceptibility to fosfomycin (99.1%), cefotaxime (98.2%), cefuroxime (97.3%), and gentamicin (95.6%).
  • Renal scars were identified in 19% of febrile UTI cases, 17% of outpatients, and 20% of inpatients.

Impact:

  • Provides essential data on antibiotic susceptibility for empirical UTI treatment in children.
  • Highlights the importance of follow-up imaging to detect renal scarring after pyelonephritis.
  • Informs clinical guidelines for managing pediatric UTIs and preventing long-term complications.

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