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Related Experiment Video

Updated: May 27, 2026

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

Published on: May 19, 2015

A longitudinal study of brain volume changes in normal aging.

Hidemasa Takao¹, Naoto Hayashi, Kuni Ohtomo

¹Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. takaoh-tky@umin.ac.jp

European Journal of Radiology

|November 23, 2011

Summary

This summary is machine-generated.

Brain atrophy accelerates with age in normal aging. This study found no gender differences in the rate of brain volume loss, indicating age is the primary factor in brain shrinkage.

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Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Published on: December 6, 2016

Area of Science:

Neuroscience
Radiology
Gerontology

Background:

Normal aging is associated with changes in brain structure.
Understanding age-related brain volume changes is crucial for differentiating normal aging from pathological conditions.

Purpose of the Study:

To evaluate the effect of normal aging on brain volumes.
To examine the effects of age and sex on the rates of global and regional brain volume changes.

Main Methods:

199 healthy subjects (65 females, 134 males; age range 38.1-82.9 years) underwent brain MRI scans twice, approximately 2 years apart.
Percentage Brain Volume Change (PBVC) was calculated using SIENA 2.6 software.
Voxel-wise analysis was performed to correlate age with regional brain changes.

Main Results:

The mean annualized PBVC was -0.23% per year.
Analysis revealed a significant effect of age on annual brain volume changes.
No significant effect of sex or sex-by-age interaction was observed on brain volume change rates.
Age correlated negatively with edge displacement values, particularly in the periventricular region.

Conclusions:

Brain atrophy rate increases with advancing age in normal individuals.
There is no discernible gender difference in the rate of age-related brain atrophy.