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Updated: May 27, 2026
Routine Screening Method for Microparticles in Platelet Transfusions
Published on: January 31, 2018
Plasma levels of platelet-derived microparticles in patients with obstructive sleep apnea syndrome
Keiko Maruyama1, Eriko Morishita, Akiko Sekiya
1Department of Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
Aim:
Obstructive sleep apnea syndrome (OSAS) has been associated with high cardiovascular morbidity and mortality, and patients suffer from repeated episodes of hypoxia. Platelet-derived microparticles (PDMPs) are released via platelet activation by various agonists, including inflammatory cytokines or high shear stress. Plasminogen activator inhibitor -1 (PAI-1) is a fibrinolytic marker and soluble fibrin (SF) is a coagulation activation marker. We examined plasma levels of PDMPs, PAI-1 and SF in patients with OSAS. We also examined the effects of continuous positive airway pressure (CPAP) on plasma levels of PDMPs.
Methods:
Full polysomnography (PSG) monitoring was performed on 27 patients. The apneahypopnea index (AHI) of 5 events/h or less than 30 events/h indicated mild to moderate OSAS, and an AHI of 30 events/h or more indicated severe OSAS. Plasma levels of PDMPs were measured using an ELISA kit, and PAI and SF were determined by a latex immunoassay. In addition, the effects of CPAP treatment were studied in 7 patients.
Result:
The plasma level of PDMPs was significantly higher in patients with severe OSAS (15.8±10.4 U/mL) than normal controls (10.8±7.1 U/mL, p < 0.05) and patients with mild to moderate OSAS (9.2±3.5 U/mL, p < 0.05). The plasma levels of PDMPs correlated with the AHI (r = 0.39, p < 0.05). In addition, CPAP treatment decreased the plasma level of PDMPs (11.9±5.6 U/mL to 6.7±3.2 U/mL, p < 0.05).
Conclusions:
Patients with OSAS might be at increased cardiovascular risk due to elevated PDMPs. Moreover a decrease in the plasma level of PDMPs by treatment with CPAP might reduce cardiovascular risk.
Insights
Patients with obstructive sleep apnea syndrome (OSAS) have higher platelet-derived microparticles (PDMPs). Continuous positive airway pressure (CPAP) treatment reduced PDMPs, potentially lowering cardiovascular risk.
Area of Science:
- Cardiovascular Science
- Sleep Medicine
- Hematology
Background:
- Obstructive sleep apnea syndrome (OSAS) is linked to significant cardiovascular risks and hypoxia.
- Platelet-derived microparticles (PDMPs) are released during platelet activation.
- PAI-1 and SF are markers of fibrinolysis and coagulation activation, respectively.
Purpose of the Study:
- To investigate plasma levels of PDMPs, PAI-1, and SF in OSAS patients.
- To assess the impact of continuous positive airway pressure (CPAP) on PDMP levels.
Main Methods:
- 27 patients underwent polysomnography (PSG) to determine the apnea-hypopnea index (AHI).
- Plasma PDMP levels were measured via ELISA; PAI and SF by latex immunoassay.
- CPAP treatment effects were evaluated in 7 patients.
Main Results:
- Severe OSAS patients showed significantly higher PDMP levels compared to controls and mild-to-moderate OSAS patients.
- PDMP levels positively correlated with the AHI.
- CPAP treatment led to a significant reduction in PDMP plasma levels.
Conclusions:
- Elevated PDMPs in OSAS patients may indicate increased cardiovascular risk.
- CPAP therapy's ability to decrease PDMPs suggests a potential mechanism for cardiovascular risk reduction in OSAS.
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