Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Water Intake

Regulation of Water Intake

Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...

Disorder of Water Balance

Disorder of Water Balance

Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...

Unrenewable Cells

Unrenewable Cells

In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of their outer...

Diabetes Insipidus II: Pathophysiology

Diabetes Insipidus II: Pathophysiology

Normally, water balance is maintained through three interconnected mechanisms: the hypothalamic thirst center, the synthesis and release of antidiuretic hormone (ADH, or vasopressin), and the kidneys' responsiveness to this hormone. ADH is synthesized in the hypothalamus, released from the posterior pituitary, and acts on the distal nephron, allowing water reabsorption and concentrated urine production.Diabetes Insipidus and Its TypesIn diabetes insipidus (DI), this regulatory system is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Hearing of Erastus "Deaf" Smith, Hero of the Texas Revolution.

The Laryngoscope·2024

Same author

Into and out of the cochlea: A re-implantation saga.

Cochlear implants international·2020

Same author

Dear.

Ear, nose, & throat journal·2019

Same author

Relation of public health staffing to follow-up after newborn hearing screening in three health districts in Georgia, 2009-2015.

International journal of pediatric otorhinolaryngology·2019

Same author

Comprehensive genetic testing of Chinese SNHL patients and variants interpretation using ACMG guidelines and ethnically matched normal controls.

European journal of human genetics : EJHG·2019

Same author

Jugular dominance is unrelated to isolated unilateral congenital aural atresia in children.

International journal of pediatric otorhinolaryngology·2018

Search research articles

Related Experiment Video

Updated: May 27, 2026

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

Severe diarrhea-dehydration in infancy permanently alters auditory function.

N Wendell Todd¹

¹Department of Otolaryngology, Emory University, 2015 Uppergate Drive NE, Atlanta, GA 30322, USA. ntodd@emory.edu

Medical Hypotheses

|November 23, 2011

Summary

Severe infant dehydration and hypoxia may cause permanent sensorineural hearing impairment. Hospitalization for diarrhea-dehydration in infancy correlated with worse hearing and lower stapedius reflex thresholds at ages 4-8 years.

More Related Videos

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

Published on: December 9, 2022

Surgical Induction of Endolymphatic Hydrops by Obliteration of the Endolymphatic Duct

Surgical Induction of Endolymphatic Hydrops by Obliteration of the Endolymphatic Duct

Published on: January 22, 2010

Related Experiment Videos

Last Updated: May 27, 2026

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

Published on: December 9, 2022

Surgical Induction of Endolymphatic Hydrops by Obliteration of the Endolymphatic Duct

Surgical Induction of Endolymphatic Hydrops by Obliteration of the Endolymphatic Duct

Published on: January 22, 2010

Area of Science:

Otolaryngology
Pediatrics
Metabolic Disorders

Background:

Sensorineural hearing impairment (SHI) has numerous causes, but metabolic stress is often overlooked.
Severe dehydration and hypoxia during infancy may induce lasting cochlear alterations.
Previous research on otitis media suggests a link between infant hospitalization for diarrhea-dehydration and later auditory function.

Purpose of the Study:

To investigate the hypothesis that transient metabolic stress from dehydration and hypoxia in infancy can lead to permanent SHI.
To explore the potential impact on auditory thresholds and uncomfortable loudness levels.
To examine the evolutionary consistency and verifiability of this hypothesis.

Main Methods:

Analysis of a population-based prospective study of otitis media.
Comparison of auditory thresholds and stapedius reflex thresholds in children with and without a history of infant hospitalization for diarrhea-dehydration.
Consideration of descriptive studies in infants undergoing ECMO or treated for congenital diaphragmatic hernia, and animal studies for verification.

Main Results:

Children hospitalized for diarrhea-dehydration as infants exhibited worse auditory thresholds at 4-8 years of age compared to those without otitis.
Lower stapedius reflex thresholds were observed in children with a history of diarrhea-dehydration hospitalization, indicating reduced acoustic energy for arousal.
The findings support the hypothesis linking infant metabolic stress to permanent SHI.

Conclusions:

Transient metabolic stress, specifically severe dehydration and hypoxia in infancy, is a potential, underrecognized cause of permanent sensorineural hearing impairment.
This condition may also reduce uncomfortable loudness thresholds.
The hypothesis is biologically plausible and amenable to further investigation through clinical and animal studies.