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Updated: May 27, 2026

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

Elastin-like polypeptide modified liposomes for enhancing cellular uptake into tumor cells.

Kyunga Na¹, Seul A Lee, Suk Hyun Jung

¹Biomaterials Research Center, Korea Research Institute of Chemical Technology, Yuseong, Daejeon, South Korea.

Colloids and Surfaces. B, Biointerfaces

|November 23, 2011

Summary

Elastin-like polypeptide (ELP) modified liposomes enhance cellular uptake in tumor cells. This novel approach improves drug delivery and holds potential for enhancing chemotherapy efficacy.

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Published on: February 9, 2019

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Area of Science:

Biotechnology
Materials Science
Nanomedicine

Background:

Polyethylene glycol-modified (PEGylated) liposomes offer prolonged circulation but suffer from poor cellular uptake.
Enhancing cellular internalization is crucial for improving the efficacy of liposomal drug delivery systems.

Purpose of the Study:

To develop and evaluate elastin-like polypeptide (ELP)-modified liposomes for enhanced cellular uptake in tumor cells.
To investigate the impact of ELP modification on liposome characteristics and drug delivery.

Main Methods:

Synthesized ELP with a thermosensitive inverse transition temperature (Tt) of 40°C for conjugation with liposomes.
Encapsulated doxorubicin (Dox) into ELP-conjugated liposomes (ELP-liposomes).
Assessed liposome size, drug release, and cellular uptake efficiency under normothermic and hyperthermic conditions using flow cytometry and confocal microscopy.

Main Results:

ELP-modified liposomes showed significantly higher cellular internalization compared to unmodified liposomes.
Liposome aggregation was observed, but temperature-triggered release via ELP phase transition was not evident.
Doxorubicin accumulation within tumor cells increased with ELP modification.

Conclusions:

ELP modification of liposomes effectively enhances cellular uptake, potentially through ELP molecule dehydration.
This strategy offers a promising approach to improve the efficacy of liposomal chemotherapy by increasing intracellular drug delivery.