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Cerebral microbleeds: histopathological correlation of neuroimaging

A Shoamanesh1, C S Kwok, O Benavente

  • 1Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, B.C., Canada. ashkan.sho@gmail.com

Cerebrovascular Diseases (Basel, Switzerland)
|November 23, 2011
PubMed
Abstract

Insights

This systematic review explored cerebral microbleeds (CMBs) and their histopathological features. While MRI shows CMBs, direct pathological validation is still needed, highlighting the need for further research.

Area of Science:

  • Neurology
  • Pathology
  • Radiology

Background:

  • Cerebral microbleeds (CMBs) are increasingly studied in cerebrovascular disease.
  • Histopathological correlation with neuroimaging findings of CMBs is an area of growing research interest.

Purpose of the Study:

  • To systematically review and characterize the pathological and radiological correlation of cerebral microbleeds (CMBs).

Main Methods:

  • A systematic literature search was performed.
  • Studies correlating histopathological characterization of CMBs with MRI findings were included.

Main Results:

  • Five studies with 18 patients were reviewed.
  • Hemosiderin deposition was the most frequent finding (49%).
  • Lipofibrohyalinosis was the most common associated vascular pathology; amyloid angiopathy was linked to dementia.

Conclusions:

  • Histopathological associations with MRI findings in CMBs have been observed.
  • Further research is warranted to validate these associations.

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