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Updated: May 27, 2026

In vitro Organoid Culture of Primary Mouse Colon Tumors
Published on: May 17, 2013
Altered expression of NFY-C and RORA in colorectal adenocarcinomas
Anastasia E Kottorou1, Anna G Antonacopoulou, Fotinos-Ioannis D Dimitrakopoulos
1Molecular Oncology Laboratory, Division of Oncology, Department of Medicine, Medical School, University of Patras, Greece. agathonisiotisa@yahoo.gr
Abstract:
NFY-C, a subunit of the transcription factor NFY, binds to the promoters of several eukaryotic genes, including cell cycle-related genes. RORA is a steroid hormone receptor implicated in a range of important cellular processes. We evaluated the expression of NFY-C and RORA in colorectal adenocarcinomas and normal colonic tissue. NFY-C expression was elevated in adenocarcinomas. Moreover, NFY-C mRNA levels correlated with time to disease progression, while NFY-C protein expression was significantly higher in metastatic disease. RORA expression was downregulated in CRC adenocarcinomas compared to normal controls and correlated with time to disease progression. The role of NFY-C and RORA in CRC merits further investigation.
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