Related Experiment Video
Updated: May 27, 2026

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice
Published on: September 2, 2020
Transient receptor potential vanilloid type 1 and pain development
Enza Palazzo1, Livio Luongo, Vito de Novellis
1Department of Experimental Medicine, Pharmacology Division, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy. enza.palazzo@unina2.it
Abstract:
Transient receptor potential vanilloid type 1 (TRPV1), a ligand-gated cation channel, is a polymodal nocitransducer widely expressed within pain transmitting/modulating areas of the peripheral and central nervous system. TRPV1 is both activated and sensitized by inflammatory endogenous mediators during inflammatory pain conditions and appears to be up regulated in neuropathic pain conditions. Owing to its role as pain integrator, its widespread expression in pain neuraxis and its involvement in pain development TRPV1 offers an exciting opportunity for therapeutic interventions in pain management. In particular, its supraspinal expression within the antinociceptive descending pathway, which includes periaqueductal grey (PAG) and rostral ventromedial medulla (RVM), represents an endogenous switch for extinguishing pain in pathological conditions.
Related Concept Videos
Thermosensation
Analgesia and Pain Management
Pain
Mechanically-gated Ion Channels
Nociception
Non-gated Ion Channels
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.
