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Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.

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Related Experiment Video

Updated: May 27, 2026

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice
06:04

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice

Published on: September 2, 2020

Transient receptor potential vanilloid type 1 and pain development.

Enza Palazzo1, Livio Luongo, Vito de Novellis

  • 1Department of Experimental Medicine, Pharmacology Division, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy. enza.palazzo@unina2.it

Current Opinion in Pharmacology
|November 23, 2011
PubMed
Summary

Transient receptor potential vanilloid type 1 (TRPV1) channels are key pain sensors. Targeting TRPV1 in the brain

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Last Updated: May 27, 2026

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice
06:04

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Published on: September 2, 2020

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

Area of Science:

  • Neuroscience
  • Pain Research
  • Molecular Biology

Background:

  • Transient receptor potential vanilloid type 1 (TRPV1) is a polymodal nocitransducer.
  • TRPV1 is expressed in the peripheral and central nervous system's pain pathways.
  • It is activated by inflammatory mediators and upregulated in neuropathic pain.

Purpose of the Study:

  • To explore TRPV1's role as a therapeutic target for pain management.
  • To investigate TRPV1's function in pain modulation within the central nervous system.

Main Methods:

  • The study focuses on the expression and function of TRPV1.
  • Analysis of TRPV1's role in pain signaling pathways.
  • Investigating supraspinal TRPV1 expression in antinociceptive pathways.

Main Results:

  • TRPV1 acts as a crucial pain integrator.
  • Its expression is vital in both inflammatory and neuropathic pain conditions.
  • Supraspinal TRPV1 in the PAG and RVM acts as an endogenous pain extinction switch.

Conclusions:

  • TRPV1 presents a promising therapeutic target for pain management.
  • Targeting supraspinal TRPV1 may offer novel strategies for pain relief in pathological conditions.