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Updated: May 27, 2026
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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
Published on: November 3, 2010
Genotyping of exercise-induced collapse in Labrador retrievers using an allele-specific PCR
Masamine Takanosu1, Hirokazu Mori, Hiroetsu Suzuki
1Nasunogahara Animal Clinic, 2-3574-98, Asaka, Ohtawara-shi, Tochigi 324-0043, Japan. mtakanosu@hotmail.com
Veterinary Journal (London, England : 1997)
|November 23, 2011
Abstract:
Exercise-induced collapse (EIC) is an autosomal recessive disorder in Labrador retrievers. In this study, an allele-specific PCR was developed to detect the point mutation G767T in exon 6 of canine DNM1, previously shown to be responsible for canine EIC. Of 133 Labrador retrievers tested in Japan, 6 (4.5%) were homozygous (EIC) and 50 (37.6%) were heterozygous (carriers) for the G767T mutation.
