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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Mapping Mammalian 3D Genome Interactions with Micro-C-XL
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Mapping Mammalian 3D Genome Interactions with Micro-C-XL

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Wrangling for microRNAs provokes much crosstalk.

Ana C Marques1, Jennifer Tan, Chris P Ponting

  • 1MRC Functional Genomics Unit, University of Oxford, Department of Physiology, Anatomy and Genetics, Oxford, UK. ana.marques@dpag.ox.ac.uk

Genome Biology
|November 23, 2011
PubMed
Summary

Combinations of microRNAs co-regulate gene transcripts with shared microRNA response elements. These interactions reveal how multiple microRNAs collectively control cell-specific gene expression networks.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression.
  • miRNA activity is often modulated by sequence elements within target transcripts.
  • Understanding miRNA-transcript interactions is crucial for deciphering gene regulatory networks.

Purpose of the Study:

  • To investigate the co-regulation of transcripts containing common miRNA response elements (MREs).
  • To explore the implications of RNA-RNA interactions in modulating transcript networks.
  • To elucidate how combinations of miRNAs collectively influence cell-specific gene expression.

Main Methods:

  • Bioinformatic analysis of transcriptomes.
  • Identification and analysis of shared MREs across different transcripts.
  • Computational modeling of miRNA-mediated regulatory networks.

Main Results:

  • Transcripts sharing MREs exhibit significant co-regulation patterns.
  • Evidence of coordinated regulation by combinations of miRNAs targeting these shared elements.
  • Demonstration of miRNA combinations fine-tuning cell-specific transcript levels.

Conclusions:

  • Shared MREs serve as hubs for co-regulated transcripts.
  • Combinatorial miRNA action is a critical mechanism for precise control of gene expression.
  • These findings provide insights into the complexity of post-transcriptional gene regulation.