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Hepatic peroxisomal and microsomal enzyme induction by citral and linalool in rats

S J Roffey¹, R Walker, G G Gibson

¹University of Surrey, Department of Biochemistry, Guildford, UK.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association

|June 1, 1990

Abstract:

The short-term effects of oral administration of citral and linalool to rats have been compared. Male Wistar rats were given, by gastric intubation, 1.5 g citral or linalool/kg body weight/day for 5 days. Citral caused peroxisome proliferation as indicated by induction of cyanide-insensitive palmitoyl-CoA oxidation and bifunctional enzyme; levels of microsomal cytochrome P-450 IVA1 were also raised. Linalool caused induction of the peroxisomal enzymes but not of cytochrome P-450 IVA1, indicating that it possesses activity somewhat different from that of citral. These results suggest that the mechanisms of peroxisome proliferation may be independent of induction of cytochrome P-450 IVA1.

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