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Related Concept Videos

Interpersonal Psychotherapy01:25

Interpersonal Psychotherapy

Interpersonal psychotherapy (IPT) is a structured, time-limited therapeutic approach initially developed to treat depression. It integrates key concepts from psychodynamic, humanistic, and cognitive-behavioral therapies, making it a uniquely eclectic framework. The therapy is rooted in the interpersonal theories of Adolph Meyer and Harry Stack Sullivan, as well as John Bowlby's attachment theory, and focuses on the interplay between interpersonal relationships and emotional well-being.
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
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Pilot and Numeric Relaying01:21

Pilot and Numeric Relaying

Pilot relaying is a type of differential protection used in power systems. It compares electrical quantities at the terminals of equipment via a communication channel instead of direct relay interconnection. This method is essential for transmission lines where the terminals are far apart, typically up to 80 km for lines with 69 to 115 kV ratings. Four types of communication channels are used for pilot relaying:
Compacting Factor test01:22

Compacting Factor test

The compacting factor test is a method used to assess the workability of concrete. It is  especially suitable for concrete mixes containing aggregates up to one and a half inches in size. This test involves specialized equipment consisting of two truncated cone-shaped hoppers and a cylinder, all with polished interior surfaces to minimize friction.
The procedure begins by placing concrete into the upper hopper without any compaction. Once filled, the bottom door of this hopper is opened,...
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Interference: Path Lengths

Consider two sources of sound, that may or may not be in phase, emitting waves at a single frequency, and consider the frequencies to be the same.
Two special sources may be considered when they are in phase. This can be easily achieved by feeding the two sources from the same source. An example would be synchronizing the two speakers by feeding them with the same source, such as the sound waves produced by a tuning fork. This setup ensures that the two sources have the same frequency and are...

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Related Experiment Video

Updated: May 27, 2026

Integration of 5G Experimentation Infrastructures into a Multi-Site NFV Ecosystem
10:15

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Published on: February 3, 2021

Another VCP interactor: NF is enough.

Conrad C Weihl1

  • 1Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA. weihlc@neuro.wustl.edu

The Journal of Clinical Investigation
|November 23, 2011
PubMed
Summary

Mutations in the VCP gene cause Inclusion body myopathy with Paget disease of the bone and frontotemporal dementia (IBMPFD). This study identifies neurofibromin-1 (NF1) as a novel VCP interactor, revealing how VCP-NF1 interactions impact brain function.

Area of Science:

  • Neuroscience
  • Genetics
  • Cell Biology

Background:

  • Inclusion body myopathy with Paget disease of the bone and frontotemporal dementia (IBMPFD) is a multisystem disorder linked to mutations in the valosin-containing protein (VCP) gene.
  • The precise mechanisms by which VCP mutations cause tissue degeneration remain largely unknown.
  • VCP is a multifunctional protein involved in various cellular processes through interactions with numerous substrates.

Purpose of the Study:

  • To identify novel VCP interactors in the central nervous system (CNS).
  • To investigate the functional consequences of VCP-neurofibromin-1 (NF1) interactions in the context of IBMPFD and related neurological disorders.

Main Methods:

  • Proteomic analysis to identify novel VCP interactors.
  • Biochemical assays to assess the impact of IBMPFD-associated VCP mutations on VCP-NF1 binding.

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  • Evaluation of synaptogenesis in relevant cellular or animal models.

    • Main Results:

    • Neurofibromin-1 (NF1) was identified as a novel VCP-interacting protein in the CNS.
    • IBMPFD-associated mutations in VCP impair its binding to NF1.
    • Disrupted VCP-NF1 interaction leads to reduced synaptogenesis.

    Conclusions:

    • Aberrant interactions between VCP and NF1 may contribute to the dementia phenotype and cognitive deficits observed in IBMPFD.
    • The VCP-NF1 interaction represents a potential therapeutic target for neurological symptoms in IBMPFD and neurofibromatosis type 1.