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Updated: May 27, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
Published on: May 31, 2017
Central nervous system regeneration does not occur
1Willow Pond House, Lymore Valley, Hampshire, UK. lee@illis.co.uk
Study Design:
Review.
Objectives:
To examine the state of research in central nervous system (CNS) regeneration and to suggest an alternative to the sterile research at the lesion site.
Setting:
Worldwide.
Methods:
A search of publications using 'PubMed' and a search of the historical literature relevant to CNS regeneration, biological models, the neurone theory, collateral sprouting, spinal shock and the central pattern generator.
Results:
There is no evidence for CNS regeneration.
Conclusion:
A century of research focussed on the lesion site has been unproductive. An alternative field of research must be developed and the best candidate is the undamaged CNS.
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