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[Monapterin and biopterin in degenerated retinas]
K Krause1, G Cremer-Bartels, H Gerding
1Universitäts-Augenklinik, Münster.
Fortschritte Der Ophthalmologie : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|January 1, 1990
Abstract:
We measured the concentrations of biopterin, neopterin and monapterin in the neuroretina of humans and different rat strains and found a relatively high amount of oxidized monapterin in these tissues. The dystrophic retinae of RCS rats revealed an inverse ratio of biopterin-to-monapterin compared to LE rats. This ratio was altered in LE rats after exposure to strong light. These results suggest that changes in pterin metabolism may correlate with retinal dystrophy.